The Williams Lake RCMP and Cariboo Chilcotin Traffic Services were called to the scene of a collision on Highway 97 at Omeretto Road, south of 150 Mile House.
It happened just after 4 am on Sunday.
Corporal Madonna Saunderson said once on scene, investigators discovered a Chevy Cruz and a Dodge pickup had collided.
Police say the driver of the Cruz, an 81-year-old man, had died at the scene while the driver of the pickup was taken to hospital with undetermined injuries.
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The highway was closed for a period of time and the investigation is ongoing and while causal factors are yet to be determined, police do not believe alcohol is involved.
– with files from Pat Matthews, My Cariboo Now staff